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Carney, F.P.; Morris, C.A.; Milthorpe, B.; Flanagan, J.L.; Willcox, M.D.P.
Eye and Contact Lens 35(6): 320-328
2009
ISSN/ISBN: 1542-233X PMID: 19816183 DOI:10.1097/icl.0b013e3181becd3cAccession:053769146
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Summary
Investigations of polymer interactions in single protein solutions is a necessary step in the elucidation of in vivo early binding events during protein deposition on hydroxyethyl methacrylate-based contact lens materials. Quantity and tenacity of binding of significant tear components to groups I and IV contact lenses was assessed. Competitive binding by these components was also examined. Adsorption on FDA groups I and IV hydrogel lenses was monitored using I-labeled protein. Lenses were incubated in increasing concentrations of radiolabeled single species proteins in solution. For competition experiments, concentration of each radiolabeled protein was held constant and the adsorption/sorption challenged with increasing concentrations of nonlabeled proteins. Lenses were soaked in phosphate-buffered saline to determine desorption. Group IV lenses bound large amounts of lysozyme, whereas group I lenses bound highest amounts of albumin. Albumin binding to both lens types was relatively strong and could not be competed from binding by other proteins lysozyme, lactoferrin, and mucin. Mucin at high concentrations tended to positively cooperate with the binding of lactoferrin and albumin to all lenses. Binding of proteins to hydroxyethyl methacrylate-based hydrogel lens surfaces is affected by charge and polymer components, and perhaps manufacturing processes. Albumin binds strongly to lens surfaces, and this may play an adverse role during contact lens wear.References
Li, R.; Guan, X.; Lin, X.; Guan, P.; Zhang, X.; Rao, Z.; Du, L.; Zhao, J.; Rong, J.; Zhao, J. 2020: Poly(2-hydroxyethyl methacrylate)/β-cyclodextrin-hyaluronan contact lens with tear protein adsorption resistance and sustained drug delivery for ophthalmic diseases Acta Biomaterialia 110: 105-118
Bohnert, J.L.; Horbett, T.A.; Ratner, B.D.; Royce, F.H. 1988: Adsorption of proteins from artificial tear solutions to contact lens materials Investigative Ophthalmology and Visual Science 29(3): 362-373
Lin, X.; Liu, J.; Zhou, F.; Ou, Y.; Rong, J.; Zhao, J. 2022: Poly(2-hydroxyethyl methacrylate-co-quaternary ammonium salt chitosan) hydrogel: a potential contact lens material with tear protein deposition resistance and antimicrobial activity Biomaterials Advances 136: 212787
Ouyang, T.; Su, S.; Deng, H.; Liu, Y.; Cui, L.; Rong, J.; Zhao, J. 2023: Superhydrophilic Poly(2-hydroxyethyl methacrylate) Hydrogel with Nanosilica Covalent Coating: a Promising Contact Lens Material for Resisting Tear Protein Deposition and Bacterial Adhesion Acs Biomaterials Science and Engineering 9(10): 5653-5665
Alqahtani, S.M.; Al Khulaifi, R.S.; Alassaf, M.; Saeed, W.S.; Bedja, I.; Aldarwesh, A.; Aljubailah, A.; Semlali, A.; Aouak, T. 2023: Preparation and Characterization of Poly(vinyl acetate-co-2-hydroxyethyl methacrylate) and in Vitro Application as Contact Lens for Acyclovir Delivery International Journal of Molecular Sciences 24(6)
Castillo, E.J.; Koenig, J.L.; Anderson, J.M. 1986: Characterization of protein adsorption on soft contact lenses. IV. Comparison of in vivo spoilage with the in vitro adsorption of tear proteins Biomaterials 7(2): 89-96
Chirila, T.V.; Morrison, D.A.; Gridneva, Z.; Meyrick, D.; Hicks, C.R.; Webb, J.M. 2005: Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour Contact Lens and Anterior Eye: the Journal of the British Contact Lens Association 28(1): 21-28
Su, G.; Zhou, T.; Zhang, Y.; Liu, X.; Zhang, A. 2016: Microdynamics mechanism of D2O absorption of the poly(2-hydroxyethyl methacrylate)-based contact lens hydrogel studied by two-dimensional correlation ATR-FTIR spectroscopy Soft Matter 12(4): 1145-1157
Mirzapour, P.; McCanna, D.J.; Jones, L. 2021: In vitro analysis of the interaction of tear film inflammatory markers with contemporary contact lens materials Contact Lens and Anterior Eye: the Journal of the British Contact Lens Association 44(5): 101430
Sen-Britain, S.; Hicks, W.L.; Hard, R.; Gardella, J.A. 2018: Differential orientation and conformation of surface-bound keratinocyte growth factor on (hydroxyethyl)methacrylate, (hydroxyethyl)methacrylate/methyl methacrylate, and (hydroxyethyl)methacrylate/methacrylic acid hydrogel copolymers Biointerphases 13(6): 06e406
Kazemi Ashtiani, M.; Zandi, M.; Shokrollahi, P.; Ehsani, M.; Baharvand, H. 2018: Surface modification of poly(2-hydroxyethyl methacrylate) hydrogel for contact lens application Polymers for Advanced Technologies 29(4): 1227-1233
Nogueira, N.; Conde, O.; Miñones, M.; Trillo, J.M.; Miñones, J. 2012: Characterization of poly(2-hydroxyethyl methacrylate) (PHEMA) contact lens using the Langmuir monolayer technique Journal of Colloid and Interface Science 385(1): 202-210
Davis, S.S.; Watson, M.A. 1981: Uptake of cationic preservatives into soft contact lens material poly 2 hydroxyethyl methacrylate Journal of Pharmacy and Pharmacology 33(Suppl): 109P
Hotta, F.; Eguchi, H.; Nakayama-Imaohji, H.; Kuwahara, T.; Tada, A.; Yagi, H.; Shimomura, Y.; Kusaka, S. 2020: Microbiome analysis of contact lens care solutions and tear fluids of contact lens wearers: Possible involvement of streptococcal antigens in allergic symptoms related to contact lens wear International Journal of Molecular Medicine 46(4): 1367-1376
Chang, Y.-C.; Su, C.-Y.; Chang, C.-H.; Fang, H.-W.; Wei, Y. 2020: Correlation between Tribological Properties and the Quantified Structural Changes of Lysozyme on Poly (2-hydroxyethyl methacrylate) Contact Lens Polymers 12(8)
Plaut, B.S.; Meakin, B.J.; Davies, D.J. 1980: The influence of various counter ions on the interaction of chlorhexidine with the hydrophilic contact lens polymer, poly(2-hydroxyethyl methacrylate) Journal of Pharmacy and Pharmacology 32(7): 453-459
Lin, Y.S.; Ming, L.J.; Peng, J.S.; Fu, Y.K.; Lee, S. 2010: Radical Annihilation of γ-Ray-Irradiated Contact Lens Blanks Made of a 2-Hydroxyethyl Methacrylate Copolymer at Elevated Temperatures Journal of Applied Polymer Science 117(6): 3114-3120
Miller, W.L.; Doughty, M.J.; Narayanan, S.; Leach, N.E.; Tran, A.; Gaume, A.L.; Bergmanson, J.P.G. 2004: A comparison of tear volume (by tear meniscus height and phenol red thread test) and tear fluid osmolality measures in non-lens wearers and in contact lens wearers Eye and Contact Lens 30(3): 132-137
Bishnoi, A.K.; Adyanthaya, R.; Singh, S.; Kapasi, A.S.; Jain, K. 2019: Effect of Er:YAG laser cavity preparation on the bond strength of 2-hydroxyethyl methacrylate-free and 2-hydroxyethyl methacrylate-rich self-etch adhesive systems: An in vitro study Dental Research Journal 16(6): 389-397
Saville, J.T.; Zhao, Z.; Willcox, M.D.P.; Blanksby, S.J.; Mitchell, T.W. 2010: Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution Investigative Ophthalmology and Visual Science 51(6): 2843-2851
