Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE 2 in LPS-induced RAW 264.7 cells (2024)

化学一氧化氮细胞毒性木犀草素抑制性突触后电位前列腺素E2 结构-活动关系药理学前列腺素E 生物化学黄酮类生物活性消炎药体外一氧化氮合酶立体化学类黄酮有机化学抗氧化剂内科学医学色谱法

作者

Ji‐Young An,Hwi‐Ho Lee,Ji‐Sun Shin,Hyung‐Seok Yoo,Jong Seon Park,Seung Hwan Son,Sang Won Kim,Jihyun Yu,Jun Lee,Kyung‐Tae Lee,Nam‐Jung Kim

出处

期刊：Bioorganic & Medicinal Chemistry Letters [Elsevier]
日期：2017-03-28 卷期号：27 (11): 2613-2616 被引量：11

链接

nih.govdoi.org

标识

DOI：10.1016/j.bmcl.2017.03.057

摘要

In an effort to identify novel anti-inflammatory compounds, a series of flavone derivatives were synthesized and biologically evaluated for their inhibitory effects on the production of nitric oxide (NO) and prostaglandin E2 (PGE2), representative pro-inflammatory mediators, in LPS-induced RAW 264.7 cells. Their structure-activity relationship was also investigated. In particular, we found that compound 3g displayed more potent inhibitory activities on PGE2 production, similar inhibitory activities on NO production and less weak cytotoxicity than luteolin, a natural flavone known as a potent anti-inflammatory agent.

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